Effect of Lidocaine in Antiarrhythmic Dosage on Postoperative Cognitive Dysfunction in Supratentorial Craniotomy Dysfunction in Supratentorial Craniotomy

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the effect of lidocaine in antiarrhythmic dosage on postoperative cognitive dysfunction in supratentorial craniotomy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Capital Medical University
• Collaborator: State University of New York - Downstate Medical Center
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• 18-60 years old, ASA physical status I or II, BMI<30

• Scheduled for elective supratentorial craniotomy

• MMSE<24 before operation

• Cooperative and given informed consent in person

Exclusion Criteria:

• History of mental or psychiatric disorders

• Contraindicated to internal jugular venous catheterization

• Pregnant or lactating female

• History of systemic malignant tumor or diabetes

• Previously treated with this protocol or participated in another study within previous 30 days

• Suspected history of allergic reaction or intolerance to amides or other anesthetic agents in this study

• History of alcohol abuse and/or drug abuse within previous one year

• History or a family history of malignant hyperthermia