Effect of Lidocaine on Postoperative Pain in Elderlypatients Undergoing Colorectal Cancer Surgery

• Status: Enrolling by invitation
• Trial end date: 2024-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients who meet the enrollment criteria will be randomized 1:1 to the lidocaine group or placebo group.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: West China Hospital
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

1. Participants were at least 60 years old;

2. American Society of Anesthesiologists (ASA) physical status I to III;

3. Body-mass index of 18-30 kg/m2;

4. Scheduled for elective colorectal surgery.

Exclusion Criteria:

1. Metastases occurring in other distant organs;

2. Severe hepatic insufficiency (aspartate aminotransferase or alanine transaminase or bilirubin >2.5 times the upper limit of normal);

3. Renal impairment (creatinine clearance <60 mL/min);

4. Cardiac rhythm disorders or systolic heart failure (second-and third-degree heart block, ejection fraction <50%);

5. Allergies to any of the trial drugs; chronic opioid use;

6. Inability to comprehend numeric rating scale.