Effect of Life Style Modification and Metformin on Hypothyroidism With Insulin Resistance

• Status: Not yet recruiting
• Trial end date: 2024-10-30
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is the effect of lifestyle modification and metformin on hypothyroidism with insulin resistance

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Metformin

Criteria

Inclusion Criteria:

• 1_ above 18 years with insulin resistance criteria according (The American Association of Clinical Endocrinologists (AACE)

• 1)BMI of 25 kg/m2 or higher

• 2)Waist circumference of more than 102 cm in men or more than 88 cm in women

• 3)Triglyceride level of 150 mg/dl . or higher.

• 4) HDL-C level of less than 40 mg/dl in men or less than 50 mg/dl in women

• 5)Blood pressure of 130 /85 mmhg or higher

• 6)Fasting glucose level of 110 ـ126 mg /dl

• 7)Glucose level of more than 140 mg/dl2 hour after administration of 75 g of glucose

2_ Patients known to have hypothyroidism and achieving diagnostic criteria of insulin resistance

Exclusion Criteria:

• Patients don't have other secondary causes of insulin resistance i.e. acromegaly, Cushing syndrome 3- patient have renal or hepatic impairment (contraindication to metformin )