Effect of Lifestyle and/or Metformin Intervention on Pregnancy Outcome, A Pilot Randomized Controlled Trial
Status:
Completed
Trial end date:
2021-06-30
Target enrollment:
Participant gender:
Summary
The purpose of pilot trial is to compare the efficacy of lifestyle intervention, metformin
intervention, lifestyle combined with metformin intervention in improving assisted
reproductive technology in non-polycystic ovary syndrome(pcos) patients with
overweight/obesity and insulin resistance compared with conventional clinical education.
Subjects who meet the inclusion criteria will be randomized to four groups: lifestyle
intervention group, metformin intervention group, lifestyle combined with metformin
intervention group, and routine clinical education group. Subjects of above three
intervention group will start ovulation stimulation treatment after reach the aim or duration
of intervention and routine clinical education group has no intervention. All subjects are
treated with the same procedures, including a long ovarian stimulation regimen, oocyte
retrieval, and fertilization, followed by a planned transfer of two day-3 embryos. The
primary outcome is ongoing pregnancy rate.