Effect of Liraglutide on Automated Closed-loop Glucose Control in Type 1 Diabetes
Status:
Completed
Trial end date:
2015-11-01
Target enrollment:
Participant gender:
Summary
"Closed loop artificial pancreas" systems have been under development for the control of
blood sugars in those living with diabetes. These systems consist of a continuous glucose
sensor, which sends a signal to a computer program that automatically determines how much
insulin to give. The computer program then tells an insulin pump to deliver the insulin.
While such systems have been tested under a number of conditions, post-meal blood sugars are
difficult to control. This study is designed to see if liraglutide, a glucagon like peptide
receptor agonist, can help minimize the post meal blood sugar spikes in subjects with type 1
diabetes while they are on a closed loop system.
Phase:
Early Phase 1
Details
Lead Sponsor:
Jennifer Sherr
Collaborators:
Juvenile Diabetes Research Foundation Yale University