Effect of Lithium Carbonate on Postoperative Sleep and Cognitive Function in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass

• Status: Not yet recruiting
• Trial end date: 2026-07-30
• Target enrollment: 0
• Participant gender: All

Summary

It has been proved that lithium carbonate can prolong slow wave sleep with few or no side-effects. The aim of the present study is to evaluate postoperative sleep quality of patients undergoing heart valve surgery with cardiopulmonary bypass taken 250mg lithium carbonate after surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: China Medical University, China
• Treatments: Calcium; Calcium Carbonate; Lithium Carbonate

Criteria

Inclusion Criteria:

• Ethnic Chinese;

• Age, 18 to 65 years old;

• Patients undergoing heart valve surgery with cardiopulmonary bypass

Exclusion Criteria:

• Preoperative Pittsburgh Sleep Quality Index global scores higher than 6

• Cognitive difficulties

• Partial or complete gastrectomy

• Previous esophageal surgery

• Previous treated by radiotherapy or surgery

• Inability to conform to the study's requirements

• Body mass index exceeding 30 kg/m2

• Deprivation of a right to decide by an administrative or juridical entity

• Ongoing participation or participation in another study <1 month ago

• Recent (< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, laxatives, proton pump inhibitors, insulin sensitizers or traditional Chinese medicine