Effect of Local Endometrial Injury on Pregnancy Outcomes During Ovulation Induction Cycles

• Status: Unknown status
• Trial end date: 2016-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of this study is to detect whether or not performing an endometrial sampling in the cycle preceding ovulation induction with clomiphene citrate can improve pregnancy outcomes in the next cycle.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Al Hayat National Hospital
• Collaborator: Menoufia University
• Treatments: Citric Acid; Clomiphene; Enclomiphene; Zuclomiphene

Criteria

Inclusion Criteria:

1. Male partner should have a normal semen count and motility according to world health organization criteria (Murray et al., 2012).

2. Primary, secondary or unexplained infertility for at least one year.

3. Failure to conceive with clomiphene citrate in spite of good follicular response for at least 3 cycles.

4. Age varies from 20-35 years with at least one year of infertility.

5. Body mass index between 19-30 kg/m2.

6. Day 2 serum FSH< 12 IU/ml.

7. Normal uterine cavity on hystrosalpingography.

8. At least one patent tube of normal appearance on HSG.

9. No previous attempts of intrauterine insemination (IUI) or in vitro fertilization (IVF).

Exclusion Criteria:

1. Infertility due to tubal factor or male factor.

2. Intrauterine organic pathology (myoma, polyp, adhesions) by hystrosalpingogram or diagnostic hysteroscope.

3. Hypogonadotrophic hypogonadism.