Effect of Losartan in Patients With Nonobstructive Hypertrophic Cardiomyopathy

• Status: Completed
• Trial end date: 2010-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether taking losartan helps people with hypertrophic nonobstructive cardiomyopathy feel better by decreasing the amount of heart muscle thickening and/or the amount of heart muscle scarring.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Treatments: Angiotensin II; Angiotensin Receptor Antagonists; Losartan

Criteria

Inclusion Criteria:

• Patients with hypertrophic cardiomyopathy

• Left ventricular outflow tract (LVOT) gradient less than 30 mm Hg at rest

• Age 18 years or older

Exclusion Criteria:

• Contraindication to losartan

• Already taking losartan

• Contraindication to MRI

• Hemodynamic instability