Effect of Losartan on Retinal Endothelial Function in Patients With Essential Hypertension
Status:
Withdrawn
Trial end date:
2006-01-01
Target enrollment:
Participant gender:
Summary
Essential hypertension is commonly associated with impaired endothelial function. The retinal
vasculature is morphologically and functionally related to the cerebral vessels because of
the common origin from the internal carotid artery. A recent study in hypertensive patients
demonstrated that endothelial function of the retinal vasculature is impaired in hypertensive
patients and that it can be restored by treatment with an AT1-receptor antagonist. It is not
clear whether this effect is due to blood pressure lowering or whether this is a blood
pressure independent effect. The present randomized, double blind study with a cross over
design addresses this issue by comparing the effects of losartan and metoprolol on retinal
endothelial function in patients with essential hypertension.