Effect of Low-dose Esketamine Combined With Target-controlled Infusion of Propofol for Painless Gastrointestinal Endoscopy

• Status: Recruiting
• Trial end date: 2022-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Purpose: 1. To determine the efficacy of low-dose esketamine in painless gastrointestinal endoscopy. 2. To determine the safety of low-dose esketamine in painless gastrointestinal endoscopy. 3. To provide a theoretical basis and new ideas for the application of esketamine as a new drug in perioperative period.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tianjin Union Medical Center
• Treatments: Esketamine; Fentanyl; Propofol

Criteria

Inclusion Criteria:

1. Subject's American Society of Anesthesiologists physical status is I-III.

2. Subject has no symptoms of allergy to anesthetics.

3. Subject has no contraindications for gastrointestinal endoscopy.

4. Subject has given written informed consent to participate.

Exclusion Criteria:

1. Subject's BMI <18 or >30

2. Subject has poorly controlled or untreated hypertension.

3. Subject has severe ischemic heart disease.

4. Subject is an untreated or undertreated patient with hyperthyroidism.

5. Subject has used drugs that affect their central nervous system.

6. .Subject has mental illness.

7. .Subject has epilepsy.

8. .Subject has a history of chronic pain.

9. .Subject is pregnant or breast-feeding.