Effect of Magnesium Sulphate Infusion on Lung Mechanics and Oxygenation in COPD Patients Undergoing Total Laryngeal
Status:
Completed
Trial end date:
2019-03-20
Target enrollment:
Participant gender:
Summary
Chronic Obstructive Pulmonary Disease [COPD] is a major cause of chronic morbidity and
mortality worldwide. COPD is characterized by persistent progressive airflow limitation that
adversely affects the ventilation/perfusion (V/Q) matching and mechanics of the respiratory
muscles and leads to hypoventilation and reduced gas transfer. COPD was identified as a
significant comorbidity associated with increased incidences of postoperative pulmonary
complications and prolonged hospital stay. MgSO4 either intravenous or inhalational has been
shown to promote bronchodilation and to improve lung function in asthmatic patients. MgSO4
either intravenous or inhalational has been shown to promote bronchodilation and to improve
lung function in asthmatic patients. Administration of MgSO4 in patients with stable COPD was
associated with reduced lung hyperinflation and improvement of respiratory muscle strength.
This randomized control trial is designed to assess the effect of intravenous MgSO4 infusion
on oxygenation and pulmonary mechanics and incidence of postoperative pulmonary complications
and length of hospital stay in patients with COPD undergoing cancer larynx surgery.