Effect of Magnesium on Dose of Rocuronium for Deep Neuromuscular Blockade

• Status: Completed
• Trial end date: 2019-07-30
• Target enrollment: 0
• Participant gender: Male

Summary

It is well known that magnesium enhances the effect of neuromuscular blocking agents such as rocuronium. However, it is not known how much magnesium can reduce neuromuscular blocking agents in maintaining deep neuromuscular blockade. Through this study, the investigators will quantitatively analyze the rocuronium saving effect of magnesium.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Seoul National University Bundang Hospital
• Treatments: Magnesium Sulfate; Rocuronium

Criteria

Inclusion Criteria:

• Patients who undergo elective robot assisted radical prostatectomy, between 20 and 80 years with a American Society of Anesthesiologists physical status classification of I or II

Exclusion Criteria:

• Conduction abnormalities in preoperative EKG such as Atrioventricular block, sinus pause

• Glomerular filtration rate <60ml/min/1.73m2

• Allergy to rocuronium, sugammadex, magnesium

• Medications that interfered with muscle activity

• Neuromuscular disease

• Hypermagnesemia