Effect of Magnesium on the Recovery Time of Neuromuscular Blockade With Sugammadex

• Status: Completed
• Trial end date: 2013-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to determine the recovery time of moderate neuromuscular blockade with sugammadex in adults pretreated with magnesium sulfate.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universidade Federal do Rio de Janeiro
• Collaborator: Hospital Federal de Bonsucesso
• Treatments: Magnesium Sulfate; Molecular Mechanisms of Pharmacological Action; Rocuronium

Criteria

Inclusion Criteria:

• Age 18-65 years

• ASA physical status 1 or 2

• weight BMI 18.5-24.9

• otorhinolaryngological surgeries

Exclusion Criteria:

• major surgery associated with massive blood loss or fluid replacement

• any known allergy to magnesium sulphate or any other study drugs

• pregnant

• anatomical malformations expected to result in a difficult intubation;

• known or suspected neuromuscular disorders and/or significant hepatic or renal dysfunction

• administration of any medication known to interfere with neuromuscular blocking agents (such as anticonvulsants, aminoglycosides, calcium channel blockers and magnesium containing medications)

• hypomagnesemia, hypermagnesemia, hypocalcemia, hypercalcemia