Effect of Melatonin and Metformin on Glycemic Control Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Melatonin is a hormone that regulates the circadian cycle in addition to having an
antioxidant effect. Patients with prediabetes state, has a deregulation of glucose metabolism
and an overproduction of reactive oxygen species caused by levels of hyperglycemia that
generate DNA modification in pancreatic beta cells, which leads to apoptosis and a deficient
production of insulin. The administration of metformin and melatonin could be a possibility
to treat and reverse the prediabetic state decreasing the glycemic levels and reactive oxygen
species production.