Effect of Melatonin on Feeding Intolerance and Incidence of Necrotizing Enterocolitis in Preterm Infants

• Status: Completed
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Assesses the efficacy of melatonin in treatment of feeding intolerance in preterm infants, the time needed to reach full enteral intake, the incidence of necrotizing enterocolitis and measures the level of tumor necrosis factor-alpha as a marker of oxidative stress.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Melatonin

Criteria

Inclusion Criteria:

• Preterm infants (<37 weeks of gestation)

• Evidence of feeding intolerance

Exclusion Criteria:

• Infants with hypoxic ischemic encephalopathy

• Infants on nothing per os

• Infants with high oxygen needs wither on invasive or non-invasive mechanical ventilation

• Major congenital anomalies

• Intracranial hemorrhage

• Respiratory distress syndrome