Effect of Melatonin on Palatal Wound Healing (Randomized Controlled Clinical Trial)

• Status: Not yet recruiting
• Trial end date: 2022-12-20
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to assess the effect of topical melatonin loaded gelatin sponge on donor palatal site healing, after palatal graft harvesting.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Salma Nabil
• Treatments: Melatonin

Criteria

Inclusion Criteria

1. Patients who have at least one site of natural dentition or dental implants that need to be treated by free palatal graft surgery for indications including progressive recession, planned prosthodontics, presence of a mucogingival deformity, or a lack of keratinized gingiva.

2. Patients who have at least 4 mm thickness of palatal mucosa (at donor site)

Exclusion Criteria:

1. History of smoking.

2. Patients who have any known disease that interfere with periodontal surgery.

3. Patients who have any dermal or autoimmune diseases.

4. Patients who have any previous adverse reactions to the products (or similar products) used in this study.

5. Pregnant and lactating women.

6. Patients who have a palatal infection.