Overview

Effect of Memantine Versus Bupropion on Smoking Relapse in Nicotine-Dependent Individuals - 3

Status:
Completed
Trial end date:
2009-05-01
Target enrollment:
0
Participant gender:
All
Summary
One of nicotine's effects on the body is at the level of the NMDA receptors in the brain. Memantine is a drug that also affects NMDA receptors, making it a candidate for the treatment of nicotine addiction. The purpose of this study is to evaluate the effectiveness of memantine using a laboratory model of smoking relapse in nicotine dependent volunteers. Investigators will compare the effects of memantine with bupropion, medication currently used to facilitate smoking cessation.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
New York State Psychiatric Institute
Collaborator:
National Institute on Drug Abuse (NIDA)
Treatments:
Bupropion
Memantine
Nicotine
Criteria
Inclusion Criteria:

- DSM-IV diagnosis of nicotine dependence with psychological dependence

- Smokes at least 15 cigarettes per day for the three months prior to enrollment

- Currently not seeking treatment for nicotine dependence

- Medically healthy on the basis of physical examination and medical history, vital
signs, EKG, and laboratory tests

- Females must use an effective method of contraception for the duration of the study

Exclusion Criteria:

- DSM-IV diagnosis of abuse or dependence on alcohol or drugs other than nicotine

- Current Axis I diagnosis or current treatment with psychotropic medications within the
three months prior to enrollment

- History of schizophrenia or other psychotic disorders, bipolar disorder, or anxiety
disorders

- Currently seeking treatment for nicotine disorders

- On parole or probation

- History of seizures or head trauma with loss of consciousness, brain contusion, or
fracture

- History of significant recent violent behavior

- Blood pressure greater than 150/90

- History of eating disorders

- History of allergic reaction to any of the study medications

- Pregnant