Effect of Metformin as Add-on Therapy to Ibuprofen on Disease Activity in Knee Osteoarthritis Patients.
Status:
Recruiting
Trial end date:
2024-06-30
Target enrollment:
Participant gender:
Summary
The goal of this randomized, double blind, placebo-controlled clinical trial is to learn
about, the effect of metformin compared with placebo-controlled group on disease activity and
interleukin-6 level in patients with knee osteoarthritis.The main question it aims to answer
is:Is Metformin as add-on therapy more effective in reducing disease activity in
Ibuprofen-treated patients with grade II-III knee osteoarthritis? Half of Participants will
receive metformin with standard of care(ibuprofen and rabeprazole) while other half placebo
and standard of care (ibuprofen and rabeprazole).
Phase:
Phase 2
Details
Lead Sponsor:
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh