Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
This study will test whether metformin administration can ameliorate androgen (male hormone)
overproduction in overweight pubertal girls with androgen excess. The investigators
hypothesize that improvement in insulin sensitivity by 12 weeks of metformin administration
will improve androgen levels after adrenal stimulation testing with adrenocorticotropic
hormone (ACTH) or ovarian stimulation testing with recombinant human chorionic gonadotropin
(rhCG).