Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour
Status:
Not yet recruiting
Trial end date:
2026-02-14
Target enrollment:
Participant gender:
Summary
The efficacy of treatment with metformin for promoting cognitive recovery and brain growth in
children/adolescents treated for medulloblastoma will be investigated in a multi-site Phase
III randomized double-blind placebo-controlled parallel arm superiority trial. Specifically,
in children/adolescents aged 7 years to 17 years and 11 months who have completed treatment
for medulloblastoma, is oral administration of metformin for 16 weeks associated with greater
improvement of cognitive function and brain growth compared to placebo administered for 16
weeks?