Effect of Metformin on Biomarkers of Colorectal Tumor Cell Growth
Status:
Terminated
Trial end date:
2015-01-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the effects of short term oral Metformin therapy
on biomarkers for tumor growth in subjects with newly diagnosed colon or rectal
adenocarcinoma.
It is hypothesized that there are independent actions of Metformin on the outcome of subjects
with colorectal cancer (CRC). Also hypothesized is that metformin effects on CRC cell growth
will correlate with this drug's effects on markers mentioned above, because the markers are
closely related to tumor growth and metastases.