Effect of Metformin on Early Pregnancy Loss in Pregnant Women With Polycystic Ovarian Syndrome

• Status: Completed
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of this work is to study the effect of metformin use for reducing early pregnancy loss in pregnant patients with Polycystic ovary syndrome (PCOS).

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Age : 25 - 35.

• Pregnant patients in their 1st trimester with history of infertility due to PCOS confirmed by at least 2 of the following criteria ( Rotterdam Criteria )

• At least twelve small follicles 2-9 mm in at least one ovary; diagnosed by ultra sound examination.

• Symptoms or biochemical evidence of hyperandrogenism; diagnosed by examination and laboratory investigations.

• Anovulation or oligo-ovulation with fewer than nine menstrual periods every 12 months : diagnosed by thorough history taking.

• Non diabetic patients who received metformin along with other ovulation-inducing drugs prior to pregnancy.

Exclusion Criteria:

• patients with other causes of infertility other than PCOS

• contraindications to metformin : liver impairment , renal failure.

• Patients with PCOS who didn't receive Metformin with drugs of induction of ovulation before pregnancy.