Effect of Metformin on Lactate Metabolism

• Status: Completed
• Trial end date: 2007-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

The main objective of this study is to evaluate the influence of metformin on lactate metabolism.

The main outcome is the lactate production following an exogenous lactate overload in healthy male subjects without metformin and one week later with metformin.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Centre de Recherche en Nutrition Humaine Rhone-Alpe
• Collaborator: Merck Sharp & Dohme Corp.
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Healthy male subjects, 18 to 30 years

• Body mass index (BMI) between 21 and 25 kg/m2 inclusive

• Informed consent

Exclusion Criteria:

• Ward of court or under guardianship (sheltered adults)

• Adult unable to express their consent

• Person deprived of freedom by judicial or administrative decision

• Person hospitalised without their consent

• Person under legal protection

• Existence of a previously diagnosed pathology

• Existence of a metabolic condition (obesity, diabetes) or a family history of such

• Ongoing medical treatment