Effect of Metformin on Patients With Osteoarthritis
Status:
Active, not recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
This randomized controlled trial aims to investigate if metformin has osteoarthritis
protective effects among overweighted knee osteoarthritis patients. The co-primary outcomes
are changes in tibiofemoral cartilage volume and Western Ontario and McMaster Universities
Arthritis Index (WOMAC) from baseline to month 24. The secondary outcomes are changes in
visual analog scale (VAS)-assessed knee pain, tibiofemoral cartilage defect,
effusion-synovitis volume, and tibiofemoral bone marrow lesion from baseline to month 24.