Effect of MgSO4 Pretreatment on Muscle Relaxation

• Status: Not yet recruiting
• Trial end date: 2024-05-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study, the effect of magnesium sulphate on the onset and duration of intense and moderate cis-atracurium induced neuromuscular blocking and on the period of no response to nerve stimulation will be evaluated in patients who will recieve magnesium sulphate (intervention group) and patients who will not recieve magnesium sulphate (comparator group).

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Magnesium Sulfate

Criteria

Inclusion Criteria:

• Age group 18-60 years old

• Both genders

• Patients who will be scheduled to undergo elective otorhinolaryngological surgery.

• Patients with BMI between 18.5 and 24.9 Kg/m2.

• Patients with American Society of Anesthesiologist physical status classification of 1 or 2

Exclusion Criteria:

• Patients who are less than 18 years old or more than 60 years old.

• Patients on medications that interfered with muscle activity.

• Allergy to medications used in this study.

• Pregnancy or suspected pregnancy.

• Neuro-muscular diseases.

• Renal or hepatic impairment.

• Hypermagnesemia (>2.5 mmol) or hypomagnesemia (<1.7 mmol).

• Patients refusing to study