Effect of Midazolam Premedication on Opioid-induced Mask Ventilation Difficulty

• Status: Not yet recruiting
• Trial end date: 2022-09-15
• Target enrollment: 0
• Participant gender: All

Summary

Mask ventilation has great importance during anesthesia induction because it is the only way to oxygenate patients who have lost consciousness and spontaneous breathing. Opioid-derived drugs used in anesthesia induction may cause difficulty in mask ventilation due to their chest wall rigidity and respiratory depressant effects. Adequate muscle relaxation and depth of anesthesia may assist with mask ventilation. It is known that premedication reduces anxiety and has a relaxing effect on airway muscles. Midazolam is frequently used in premedication because it has a rapid onset of action and does not cause hemodynamic changes. In addition, midazolam may relax the airway by acting directly on the airway smooth muscle and thus facilitate mask ventilation during anesthesia induction. In this study, the investigators will evaluate the effect of midazolam premedication on the mask ventilation after induction with remifentanil.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Karaman Training and Research Hospital
• Treatments: Midazolam

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) class I and II patients

• Patients who are scheduled for any elective surgery under general anesthesia

Exclusion Criteria:

• age <18 or >60 years

• current cervical spine disease or history of cervical spine surgery;

• morbid obesity (body mass index, ≥35 kg/m2);

• sleep apnea;

• craniofacial anomaly;

• allergic reaction to midazolam and remifentanil

• chronic use of opioid, benzodiazepine, antipsychotic medications

• pregnancy

• presence of muscle weakness or dyspnea