Effect of Midazolam Premedication on Opioid-induced Mask Ventilation Difficulty
Status:
Not yet recruiting
Trial end date:
2022-09-15
Target enrollment:
Participant gender:
Summary
Mask ventilation has great importance during anesthesia induction because it is the only way
to oxygenate patients who have lost consciousness and spontaneous breathing. Opioid-derived
drugs used in anesthesia induction may cause difficulty in mask ventilation due to their
chest wall rigidity and respiratory depressant effects. Adequate muscle relaxation and depth
of anesthesia may assist with mask ventilation. It is known that premedication reduces
anxiety and has a relaxing effect on airway muscles. Midazolam is frequently used in
premedication because it has a rapid onset of action and does not cause hemodynamic changes.
In addition, midazolam may relax the airway by acting directly on the airway smooth muscle
and thus facilitate mask ventilation during anesthesia induction. In this study, the
investigators will evaluate the effect of midazolam premedication on the mask ventilation
after induction with remifentanil.