Effect of Minocycline on Pain Caused by Nerve Damage

• Status: Completed
• Trial end date: 2014-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if minocycline is effective in the treatment of neuropathic pain. The effect of minocycline will be compared to the effect of placebo and amitriptyline.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ziekenhuis Oost-Limburg
• Treatments: Amitriptyline; Amitriptyline, perphenazine drug combination; Minocycline

Criteria

Inclusion Criteria:

Lumbar radicular pain due to disc herniation, failed back surgery syndrome or spinal canal stenosis causing neuropathic pain

Exclusion Criteria:

1. Diabetic, alcoholic or drug induced polyneuropathies

2. Depression or psychiatric comorbidity affecting pain sensation.

3. Use of antidepressants

4. Fibromyalgia and Chronic Fatigue Syndrome

5. Pregnancy.

6. Previous spinal cord damage

7. Malignancies

8. Allergy to minocycline or amitriptyline