Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft

• Status: Completed
• Trial end date: 2012-04-01
• Target enrollment: 0
• Participant gender: All

Summary

N-acetylcysteine may prevent acute kidney injury in high risk patients undergoing off-pump coronary artery bypass graft.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Acetylcysteine; N-monoacetylcystine

Criteria

Inclusion Criteria:

• Patients undergoing off-pump coronary artery bypass surgery and meets more than one of the following criteria;

• preoperative serum creatinine > 1.4 mg/dl

• Age > 70 years

• Diabetes mellitus

• left ventricular ejection fraction < 35 % or congestive heart failure (NYHA III or IV)

• emergency surgery or re-operation

Exclusion Criteria:

• preoperative acute renal failure, patients on dialysis, use of N-acetylcystein within 5 days of surgery, history of hypersensitivity to N-acetylcystein