Effect of N-methyl D-aspartate (NMDA) Receptor Antagonist Dextromethorphan on Opiods Analgesia and Tolerance in Pediatric Intensive Care Unit Patients

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Effect of N-methyl D-aspartate (NMDA) receptor antagonist Dextromethorphan on Opiods analgesia and tolerance in Pediatric Intensive Care Unit Patients

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: King Abdullah International Medical Research Center
• Treatments: Dextromethorphan; N-Methylaspartate

Criteria

Inclusion:

• Patients above 2 years, admitted in PICU

• On Morphine or Fentanyl infusions for more than 48 hours

Exclusion Criteria:

• Patients under 2 years of age

• Patients with anticipated PICU length of stay less than 3 days.

• Patients shall be excluded if Morphine or Fentanyl infusions not continued for the minimum duration of 72 hours after enrollment

• Patients develops hemodynamic instability

• Patients with Hepatic failure

• Withdrawal request by parent(s)/guardian/family