Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture

• Status: Recruiting
• Trial end date: 2031-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are excellent medications for providing pain control in certain patients. There is some data to suggest that NSAIDs can be used to reduce postoperative pain and narcotic use in patients who had undergone carpal tunnel release. There are mixed results about the effect of bone healing in adult patients with broken bones. The investigators hypothesize that NSAID administration in the acute phase of distal radius fracture healing will be non-inferior for pain control and decrease the use of opioid analgesics compared to patients who take acetaminophen for pain control during this same time period. Furthermore, the investigators hypothesize that patients will have similar or better patient reported outcomes, range of motion, and strength with the administration of NSAIDs.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Missouri-Columbia
• Treatments: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Ibuprofen

Criteria

Inclusion Criteria:

• Age ≥ 18

• Distal radius fracture

Exclusion Criteria:

• Contraindication to NSAID use (cannot tolerate, gastritis, ulcers)

• Inability to take breakthrough medications

• Regular use of NSAIDs

• Regular use of Narcotics

• Open fracture

• Other orthopaedic injuries (polytrauma)

• Pathologic fracture

• Previous injury to the bone

• Pregnant or plan to become pregnant

• Unable to sign informed consent