Effect of NSAID on Travoprost-induced Conjunctival Hyperemia and IOP Reduction in Normal Eyes
Status:
Completed
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
PG-analogues induce hyperemia as one of side effects in addition to IOP reduction.
IOP reduction is caused by direct FP receptor stimulation, but the cause of hyperemia is not
clarified.
Because FP receptor stimulation induce intrinsic production of PGs, hyperemia or IOP
reduction may be due to secondary induced PGs.
Thus, pretreatment with NSAID may affect the PG-analogue induced hyperemia or IOP reduction.