Effect of Naloxegol on Gastric, Small Bowel, and Colonic Transit in Healthy Subjects
Status:
Completed
Trial end date:
2017-05-10
Target enrollment:
Participant gender:
Summary
This research study was being done to study the effect of codeine and Naloxegol for 3 days
compared to placebo on the movement of food through the colon of healthy individuals. Codeine
is a commonly used pain-relieving drug that often causes constipation as an unwanted side
effect. Naloxegol is a medication recently approved by the FDA for treatment of constipation
induced by Codeine.
The hypothesis for this study was that Naloxegol reduces the retardation of small bowel and
colonic transit induced by codeine in healthy participants.