Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers
Status:
Completed
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
Gastroduodenal ulcers are extremely common in the community today. Though much has been
written and observed concerning how ulcers form, not much has been described in the human
model concerning how these ulcers heal. As numerous patients already suffer from
gastrointestinal ulcers, further clarification of ulcer healing would be valuable in the
treatment and management of these patients. The goal of this study is to investigate the
effects of naproxen, aspirin, celecoxib, and clopidogrel on biopsy-induced gastroduodenal
lesions in order to elucidate the mechanisms of ulcer healing. This single site,
single-blind, randomized, placebo-controlled, one-week prospective study will examine ulcer
healing through endoscopic, immunohistologic, and molecular PCR modalities.