Effect of Nebivolol on Oxidative Stress and Endothelial Progenitor Cells
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Hypertension, or high blood pressure, is a common disease that affects many Americans, and
can lead to devastating consequences such as heart attack, stroke, and death if not treated.
Nebivolol is a medication that has been recently approved by the FDA for the treatment of
hypertension. Nebivolol has an unusual profile compared to other medications, in that its
effects may be related to release of a substance called nitric oxide. Nitric oxide is
released from the cells lining the blood vessels, and nebivolol may stimulate these cells to
release more nitric oxide. Our study will investigate whether treatment with nebivolol, as
compared to another medication called metoprolol, in hypertensive subjects will be more
effective in protecting blood vessels against the harmful effects of high blood pressure. The
mechanisms we will investigate include oxidative stress markers and circulating levels of
endothelial progenitor cells.