Effect of Neem and NaOCl on Postoperative Pain and Amount of Endotoxins

• Status: Unknown status
• Trial end date: 2020-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to compare the effect of Neem (azadirachta indica) and 2.5% sodium hypochlorite as root canal irrigants on the intensity of post-operative pain and the amount of endotoxins in necrotic teeth.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Eusol; Root Canal Irrigants; Sodium Hypochlorite

Criteria

Inclusion Criteria:

• 1- Mandibular molar teeth:

• Diagnosed clinically with pulp necrosis.

• Absence of spontaneous pain

• Pain on palpation or tenderness to percussion.

• Periradicular radiolucency or widening of periodontal membrane space. 2- Patients' acceptance to participate in the trial. 3- Patients who can understand NRS scale and can sign the informed consent.

Exclusion Criteria:

• 1. Primary teeth and permanent teeth with immature roots which require special endodontic treatment protocol that seeking for obtaining good apical seal, proper cleaning, shaping and obturation 2. Patients who have received antibiotics for the last 3 months before the study or any medication that could alter their perception of pain, inflammation and infection .

3. Teeth previously accessed or endodontically treated as they have low success rate .

4. Patients with diabetes, immune-compromising and immune-suppresion disease as the healing is much more slowly and more liable to infection .

5. Pregnant patients to avoid exposure to radiograph. Moreover, pain perception may be altered due to hormonal changes .

6. Teeth with deep pocket >4 mm as it has poor prognosis and deep pockets are harbor area for infection which need specific surgical and periodontal treatment .

7. Teeth that could not be isolated with a rubber-dam or could not be restorable.

8. Tooth associated with vertical root fracture, coronal perforation, calcification and external or internal root resorption as it has poor prognosis.