Effect of Neuromuscular Blockade and Reversal on Breathing

• Status: Completed
• Trial end date: 2018-09-01
• Target enrollment: 0
• Participant gender: Male

Summary

In this study the investigators will assess (i) the effect of partial neuromuscular blockade (NMB; TOF ratio 0.8 and 0.6) induced by low-dose rocuronium on the ventilatory response to isocapnic hypoxia and (ii) the effect over time (from TOF 0.6 to TOF 1.0) of the reversal by sugammadex, neostigmine or placebo in healthy volunteers.

Additionally the investigators will assess the effect of partial NMB (TOF ratio 0.6) induced by low-dose rocuronium on the ventilatory response to hypercapnia and effect over time (from TOF 0.6 to TOF 1.0) of the reversal by sugammadex, neostigmine or placebo in healthy volunteers.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Leiden University Medical Center
• Treatments: Neostigmine; Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

• male gender

• age 18 years and older

• body mass index < 30 kg/m2.

Exclusion Criteria:

• Known or suspected neuromuscular disorders impairing neuromuscular function;

• allergies to muscle relaxants, anesthetics or narcotics;

• a (family) history of malignant hyperthermia or any other muscle disease;

• any medical, neurological or psychiatric illness (including a history of anxiety).