Effect of Neuromuscular Blockade on Operating Conditions and Overall Satisfaction During Spinal Surgery

• Status: Completed
• Trial end date: 2017-02-16
• Target enrollment: 0
• Participant gender: All

Summary

The investigators aim to investigate operating conditions, postoperative recovery and overall satisfaction of surgeons between deep neuromuscular blockade (NMB) group and restricted NMB group during spinal surgery under general anesthesia. The investigators hypothesize that this study can present good surgical conditions, postoperative recovery outcomes and overall satisfaction of surgeons in deep NMB group, thereby proving the advantages of deep NMB as well as flaws of restricted NMB in spine surgeries.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Korea University Guro Hospital
• Collaborator: Merck Sharp & Dohme Corp.
• Treatments: Rocuronium

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) physical status I-II adult patients scheduled for elective spinal (cervical or lumbar) surgery under general anesthesia

Exclusion Criteria:

• Pregnancy

• Present medication known to interfere with neuromuscular blockade

• Diseases affecting neuromuscular transmission

• History of hypersensitivity on rocuronium or sugammadex

• Emergent spinal surgery

• Spinal surgeries which have lesions more than 3 spinal levels

• Spinal surgeries which have duration less than 1 hour

• Spinal surgeries which are not performed under prone position

• Spinal surgeries which are not performed under total intravenous anesthesia (TIVA).

• Patients who will have hemodynamic instability (mean blood pressure increase or fall of > 30% from baseline lasting for more than 5 min) during surgery

• Patients who will have blood loss > 1 L during surgery

• MEP monitored spinal surgeries