Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery

• Status: Completed
• Trial end date: 2017-09-15
• Target enrollment: 0
• Participant gender: All

Summary

The investigators will conduct a prospective, randomized trial to assess the impact of neuromuscular blockade on early (<72 hours post-ICU admission) postoperative respiratory complications in cardiac surgical patients. The study will compare continual neuromuscular blockade with cisatracurium to a single dose of succinylcholine during general anesthesia for cardiac surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Chicago
• Treatments: Anesthetics; Atracurium; Cisatracurium; Succinylcholine

Criteria

Inclusion Criteria:

• Elective cardiac surgery (CABG, valve replacement, CABG + valve) requiring cardiopulmonary bypass

Exclusion Criteria:

• Emergency surgery

• Extremes of age

• Previous cardiac surgery

• Clinical contraindications to succinylcholine or cisatracurium

• Anticipated difficult tracheal intubation

• Preoperative mechanical ventilation

• Preoperative pharmacologic/mechanical hemodynamic support