Effect of Neutralization of Endogenous Acid Production on BMD and Bone Microarchitectural

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Hypothesis: Neutralization of acid production induced by the Western diet with oral administration of potassium citrate increases bone mineral density and bone mass as well as skeletal muscle mass and strength in elderly people (> 65y).

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Kantonsspital Baselland Bruderholz
• Treatments: Citric Acid; Potassium Citrate

Criteria

Inclusion Criteria:

• Men and women, 65 to 80y, tscores at L2-L4 0 to -2.5

Exclusion Criteria:

• Treated or necessity to treat low BMD (t-score L2 to L4 <-2.5)

• Any major medical illness that would possibly need hospitalization and/or be followed by foreseeable complications within 12 months and/or have a life-expectancy of less than 5 years

• Stable serum creatinine > 150 umol/l and/or known Type IV renal-tubular acidosis (hyperkalemia)

• vegetarians

• concommitant drug prescriptions: systemic and topical glucocorticoids, systemically acting estrogens (topical allowed): both within the last 6 months. antiosteoporosis drugs: bisphosphoponates, fluoride, calcitonin, all within the previous 12 months.

• vitamin D deficiency at screening visit

• technical difficulties to delineate bone area of interest during the screening visit