Effect of Neutrophil Elastase Inhibitor on Lung Injury After Esophagectomy

• Status: Completed
• Trial end date: 2009-03-01
• Target enrollment: 0
• Participant gender: All

Summary

A neutrophil elastase inhibitor may have effect on suppression of the lung injury after thoransthoracic esophagectomy. The investigators hypothesized that postoperative complication, particularly respiratory complication may be reduced by neutrophil elastase inhibitor after esophagectomy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yokohama City University Medical Center
• Treatments: Proteinase Inhibitory Proteins, Secretory; Sivelestat

Criteria

Inclusion Criteria:

• Thoracic esophageal squamous cell carcinoma

Exclusion Criteria:

• Preoperative chemoradiotherapy

• Cardiovascular disease with NYHA grade III or IV

• Pulmonary disorder with Hugh-Jones classification II, III, IV, or V, preo

• Liver cirrhosis

• Renal failure