Effect of Nicardipine on Renal Function in Deliberate Hypotension

• Status: Completed
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to demonstrate the effect of nicardipine on renal function with creatinine clearance, serum cystatin C, urine output and fractional excretion of sodium during deliberate hypotension for spine surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Nicardipine; Remifentanil

Criteria

Inclusion Criteria:

• Patients undergoing anterior or posterior spine interbody fusion

Exclusion Criteria:

• Patients with American Society of Anesthesiologists physical status III or IV

• Liver dysfunction with aspartate transaminase/alanine transaminase greater than 60/60 IU/L

• Cerebrovascular disease

• Anemia of less than hematocrit 24%

• Diabetes mellitus

• Severe malnutrition

• those diuretics or antihypertensive drugs