Effect of Nortriptyline on Abdominal Pain/Discomfort and Quality of Life in Patients With Nonulcer Dyspepsia

• Status: Terminated
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if use of Nortriptyline will improve symptoms and quality of life in patients who have nonulcer dyspepsia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cleveland Clinic Florida; The Cleveland Clinic
• Treatments: Antidepressive Agents; Nortriptyline

Criteria

Inclusion Criteria:

• Men and Women

• Ages 18-65

• Meet Rome III criteria for functional dyspepsia

• Endoscopy within 1 year

Exclusion Criteria:

• Allergic reaction or history of adverse events with Nortriptyline or tricyclic antidepressants

• Organic cause found on physical examination

• Organic cause found on lab work: Complete Blood Count, Comprehensive Metabolic Panel, Thyroid stimulating hormone, Tissue transglutaminase Immunoglobulin A

• Predominantly Gastroesophageal reflux symptoms

• Current Helicobacter pylori infection

• History of Peptic ulcer disease

• Non steroidal antiinflammatory use use > 2x/wk

• Pregnant or planning pregnancy

• History of major depression

• Abdominal surgery in the last year