Effect of Number of Meals on Metabolism After Weight Loss Surgery

• Status: Completed
• Trial end date: 2014-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effect of meal size and texture on the levels of incretin hormone, GLP-1, after Gastric Bypass Surgery (GBP). Patterns of food intake change after bariatric surgery and patients often eat multiple small low-calorie meals, a pattern that may affect blood glucose as well as incretin levels. Whether the release of GLP-1 after an oral challenge or a single liquid meal has any physiological relevance in 'real life' setting of multiple small meals diet is unclear.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Columbia University
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Acetaminophen

Criteria

Inclusion Criteria: morbidly obese individuals, BMI above 35 and less than 50 kg/m2 who chose GBP as treatment for their obesity

• Must be able to attend all study visits at St. Luke's Roosevelt Hospital Center in Manhattan, New York City

• Individuals with or without Type 2 Diabetes Mellitus are eligible

Exclusion Criteria:

• Patients with abnormal thyroid, renal function, known malabsorption syndrome or a seizure disorder requiring anti epileptic therapy, and/or elevation of liver enzymes three times above the normal limit.

• Patients with intestinal conditions such as chronic diarrhea, diverticulitis, or irritable bowel syndrome.

• Currently pregnant or nursing.

• Known cardiovascular disease.

• Patient with current mucosal (gastrointestinal, respiratory, urogenital) or skin (cellulitis) infection

• Any other condition which, in the opinion of the investigators, may make the candidate unsuitable for participation in this study.

• past history of severe food allergy

• History of Type 1 Diabetes Mellitus

• Individuals taking insulin, thiazolidinedione, exenatide, or DPP-IV inhibitors