Effect of Obeticholic Acid on Transport of Bile Acids in PBC Examined by 11C-cholyl-sarcosine PET/CT
Status:
Completed
Trial end date:
2018-09-20
Target enrollment:
Participant gender:
Summary
This is an investigator-initiated, double-blind crossover study on the mechanism of OCA
treatment of patients with PBC.
Hypothesis and significance
The investigators will test the hypothesis that OCA administration to patients with PBC
increases hepatobiliary secretion of cholylsarcosine assessed by PET/CT using 11C-labeled
cholylsarcosine (11C-CSar) as tracer.
The results of this research project will elucidate the mechanism of the effect of using OCA
therapeutically in patients with PBC.