Effect of Olanzapine on Sleep Electroencephalogram (EEG) in Schizophrenia Patients

• Status: Completed
• Trial end date: 2009-04-01
• Target enrollment: 0
• Participant gender: Male

Summary

Acute and sub-chronic administration of olanzapine has shown a favourable effect on the sleep disturbances in previously medicated schizophrenia patients with predominantly negative symptoms. The present study will be carried out to clarify the effect of olanzapine on polysomnographic profiles of schizophrenia patients in an acute phase of illness after controlling for the drug effects.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Central Institute of Psychiatry, Ranchi, India
• Treatments: Olanzapine

Criteria

Inclusion Criteria:

1. Male patients fulfilling International Classification of Diseases-10 Diagnostic Criteria for Research for schizophrenia

2. Aged 18-50 Yrs

3. Drug naïve or drug free (not receiving any psychotropic medication for the past 4 months)

4. Consenting

Exclusion Criteria:

1. Any comorbid psychiatric illness

2. Significant medical or neurological illness

3. History of significant head injury, epilepsy

4. Substance use in the past 4 months excluding nicotine and caffeine

5. Presence of a primary sleep disorder