Effect of Omega-3 Fatty Acids on Methotrexate Induced Hepatotoxicity in Children With Acute Lymphoblastic Leukemia

• Status: Completed
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Study the role of oxidative stress in methotrexate induced hepatic damage, and the possible protective effect of OMEGA-3 fatty acids against methotrexate hepatotoxicity using clinical and biochemical parameters.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nancy Samir Elbarbary
• Treatments: Methotrexate

Criteria

Inclusion Criteria:

• Child age: less than 17 years old.

• Taking oral methotrexate in maintenance therapy.

• Patients are at cycle one day zero.

Exclusion Criteria:

• Child infected by hepatitis B or C viruses.

• Child taking medications or having a condition causing elevation in liver enzymes level other than methotrexate.(eg:thrombosis ,antibiotic therapy, infiltrating malignancy ,auto immune manifestations or having TPN)

• Child remission.

• Child death

• Child drop out due to non compliance