Effect of Opioids on Ventilation in Children With Obstructive Sleep Apnea

• Status: Completed
• Trial end date: 2020-08-30
• Target enrollment: 0
• Participant gender: All

Summary

The sole objective in this study is to evaluate if routine amounts of opioids given for tonsillectomy in children have greater amounts of respiratory depression in children with documented obstructive sleep apnea when compared with patients that do not have obstructive sleep apnea

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Baylor College of Medicine
• Treatments: Analgesics, Opioid; Fentanyl

Criteria

Inclusion Criteria:

• tonsillectomy or adenotonsillectomy

• Ages 2 to 8 years

• Polysomnography with AHI >6 (study group)

• Polysomnography with AHI =0 or negative OSA 18 questionnaire (control group)

Exclusion Criteria:

• Ages >8 years

• Patients requiring pre-medication

• Parental refusal

• Opioid allergy/intolerance

• Patients requiring propofol for intubation

• Patients with known or suspected difficult airway

• Obesity with body mass index exceeding 30- (control group only)

• Known cardiovascular disorders

• Known pulmonary disorders aside from asthma

• Patients with chronic oxygen requirement

• History of Prematurity <35 weeks of gestation

• No recent URI

• Personal of family history of malignant hyperthermia