Effect of Oral Melatonin on Postoperative Analgesia After Thoracotomy in Infants
Status:
Recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
Thoracotomy pain is one of the severest pain that should be taken seriously especially in
children. (1) Inadequate postoperative pain management can compromise respiratory function,
delay postoperative extubation, increase the cost and delay hospital discharge.
Opioids are the most commonly used analgesics to manage postoperative pain; however, they
have many possible unfavorable side effects, such as nausea, vomiting, pruritus, and
respiratory depression. (3) Melatonin is an endogenous indoleamine secreted by the pineal
gland. It has several important physiological functions, including regulation of the
circadian rhythms, modulation of season changes, antioxidant, oncostatic, anti-inflammatory,
and anticonvulsant effects. (4)