Effect of Oral Melatonin on Postoperative Analgesia After Thoracotomy in Infants

• Status: Recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Thoracotomy pain is one of the severest pain that should be taken seriously especially in children. (1) Inadequate postoperative pain management can compromise respiratory function, delay postoperative extubation, increase the cost and delay hospital discharge.

Opioids are the most commonly used analgesics to manage postoperative pain; however, they have many possible unfavorable side effects, such as nausea, vomiting, pruritus, and respiratory depression. (3) Melatonin is an endogenous indoleamine secreted by the pineal gland. It has several important physiological functions, including regulation of the circadian rhythms, modulation of season changes, antioxidant, oncostatic, anti-inflammatory, and anticonvulsant effects. (4)

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• ASA I, II

• less than 18months.

• males and females.

• scheduled for thoracotomy for closed cardiac surgery.

Exclusion Criteria:

• airway abnormalities.

• heart failure.

• endocrine disorders.

• Patients with hypersensitivity to any drug.

• beta blockers, any analgesics recieved within 24 h before surgery, or any psychotropic drugs.

• hepatic, renal diseases neuromuscular disease,

• coagulopathy.

• a history of hyperthermia.

• infection at the site of the block.