Effect of Oral Nutritional Supplements on Body Weight Loss of Patients With Nasopharyngeal Carcinoma
Status:
Recruiting
Trial end date:
2023-07-01
Target enrollment:
Participant gender:
Summary
Concurrent chemoradiotherapy(CCRT) is the principal treatment for nasopharyngeal
carcinoma(NPC). Studies have shown that malnutrition is very common in patients with NPC
after chemoradiotherapy. Malnutrition can lead to weight loss, treatment interruption,
prolonged stay in hospital, increased treatment costs, reduced tolerance to anti-tumor
therapy, reduced quality of life and shortened survival time. Nutritional intervention can
improve the nutritional status, reduce treatment-related toxicity and improve the survival of
patients with NPC.
The first choice of nutritional intervention is oral nutritional supplements(ONS). Some
retrospective studies with small samples have found that early nutritional intervention can
reduce weight loss and severe oral mucositis in patients with NPC, compared with late
nutritional intervention. Therefore, the investigators proposed the hypothesis that ONS from
the beginning of radiotherapy can reduce the nutritional impairment, treatment-related
toxicity and treatment costs of patients with NPC, and improve their quality of life. The aim
of this multicenter randomized controlled clinical trial is to evaluate the efficacy and cost
utility of ONS from the beginning to the end of radiotherapy.
Phase:
N/A
Details
Lead Sponsor:
Jinsheng Hong
Collaborators:
900th hospital of the joint logistics team, PLA Fujian Cancer Hospital Fujian Medical University Union Hospital Hunan Cancer Hospital Jiangxi Provincial Cancer Hospital Nanfang Hospital of Southern Medical University Quanzhou First Hospital Affiliated to Fujian Medical University The First Affiliated Hospital of Xiamen University The Nanping First Affiliated Hospital of Fujian Medical University The Second Affiliated Hospital of Fujian Medical University Zhangzhou Affiliated Hospital of Fujian Medical University Zhongshan Hospital Xiamen University