Effect of Oral Preparation on Bacterial Colonization of the Pharyngeal Mucosa in Surgery of Head and Neck Cancer

• Status: Completed
• Trial end date: 2018-09-05
• Target enrollment: 0
• Participant gender: All

Summary

Surgical site infections are an important health indicator for hospitals and a significant medico-economic issue.

The aim of the study is to assess the impact of chlorhexidine mouthwash performed before surgery on the bacterial colonization of the pharyngeal mucosa.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rennes University Hospital
• Treatments: Chlorhexidine; Chlorhexidine gluconate

Criteria

Inclusion Criteria:

• Histological evidence of cancer regardless of histological type

• Surgical treatment requiring mucosal effraction regardless of the surgical approach;

• Patient over 18 years old;

• Oral cancer, oropharyngeal cancer, hypopharyngeal cancer or laryngeal cancer;

• Written and informed patient consent

Exclusion Criteria:

• Concomitant Vascular Interventions;

• Interventional radiology;

• Needing of second surgery at a same location during the 30 postoperative days);

• Cancer of the paranasal sinus, nasal cavity, skull base, salivary glands, skin,

• Neck dissection without mucosal effraction

• Thyroid or parathyroid surgery

• Size tumor forbidden tumor surgery

• Allergy to any tested product;

• Concurrent infection the day before or day of surgery

• Protected adults (guardianship) and persons deprived of liberty